Njengefom yedosi yeyeza eqhelekileyo, ukufunxwa kwe-capsule kubandakanya izigaba ezininzi. Ukusuka ekungeneni emzimbeni womntu ukuya ekusebenziseni isiphumo sawo sonyango, inyathelo ngalinye liphenjelelwa yiphysiological kunye neyeza{1}}izinto ezithile. Oku kulandelayo yinkcazo eneenkcukacha egubungela ukuchithwa kwe-capsule, ukukhutshwa kweziyobisi, iindlela zokufunxa, kunye nezinto ezinempembelelo.
Inkqubo yokufunxa iqala ngokuchithwa kwe-capsule kwindlela yokugaya. Emva kokungeniswa, i-capsule ihamba phantsi kwi-esophagus ukuya esiswini, apho i-asidi yesisu kunye ne-enzymes yokugaya iqala ukusebenza kwiqokobhe layo. Amaqokobhe eeCapsule enziwa ngemathiriyeli efana negelatin okanye isityalo-seselulosi esekwe. Ezi zixhobo zithambisa ngokuthe ngcembe kwaye ekugqibeleni ziqhekeke okanye zinyibilike kwindawo ene-asidi yesisu kunye nendalo yealkaline yamathumbu. Ubude bale nkqubo buhluka ngokuxhomekeka kwi-capsule kunye nokwahlukana komntu ngamnye, kodwa ngokuqhelekileyo ihlala esiswini kwimizuzu engama-30 ukuya kwiiyure ze-2. Kuphela emva kokuba iqokobhe linyibilike ngokupheleleyo apho iyeza linokuthi likhutshwe.
Ukukhutshwa kweziyobisi linyathelo elibalulekileyo lokufunxa. Nje ukuba iqokobhe le-capsule linyibilike, amasuntswana eziyobisi angaphakathi okanye ipowder akhululwa kwi-gastric or intestinal fluids. Izinga lokukhululwa linokwahluka kwiziyobisi ezahlukeneyo; ezinye ziyilelwe ukukhululwa kwangoko, ngelixa ezinye zikhulula ngokucothayo, ngokuxhomekeke kuyilo loyilo, olufana nomgangatho, oluzinzileyo -ukukhutshwa, okanye okulawulwayo{3}}ukukhupha iicapsules. Iyeza elikhutshiweyo linokuba luhlobo lwegranules, umgubo, okanye ulwelo, kwaye imeko yalo yomzimba ichaphazela ukunyibilika kwayo kunye nesantya sokusasazeka kwindlela yokwetyisa.
Indawo ephambili yokufunxa ichiza lithumbu elincinci. Amathumbu amancinci yeyona ndawo iphambili yokufunxa iziyobisi, njengoko indawo yayo ye-mucosal igqunywe kwi-microvilli, eyandisa kakhulu indawo ephezulu. Ngapha koko, iiprotheyini zokuthutha kwiiseli ze-epithelial zamathumbu amancinci zinokukhetha ukuthutha iimolekyuli zamachiza. Iimolekyuli zamachiza ziwela i-mucosa yesisu ngokusasazwa kwe-passive okanye ukuthutha okusebenzayo ukungena kwinkqubo yokujikeleza. Isantya kunye nokusebenza kakuhle kokufunxa kuphenjelelwa zizinto ezininzi, kubandakanywa iipropathi ze-physicochemical yechiza ezifana nobunzima bemolekyuli, ukunyibilika, kunye ne-lipophilicity, kunye nokungena kunye nobukhulu bezinto ze-capsule.
Ixesha elimiselweyo lokufunxa ichiza libanzi kakhulu, ngokuqhelekileyo liqala kwimizuzu engama-30 ukuya kwiiyure ezi-6. Amayeza alulwelo afunxwa ngokukhawuleza kunawo aqinileyo, ngelixa i-capsule{3}esekelwe kwiziyobisi zifunxwa kwisithuba seeyure ezi-2 ukuya kwezi-3, kunye{6}}nokukhutshwa kwemixube okuthatha ixesha elide. Ukongeza, iyantlukwano yomntu ngamnye inokuchaphazela iziphumo zokufunxa, kubandakanya iminyaka, isondo, izinto zofuzo, kunye ne-gut microbiome. I-gut microbiome inokuphembelela ngokungangqalanga ukufunxwa kwechiza ngokusebenza kweyeza okanye ngokumodareyitha imekobume yamathumbu.
Ekugqibeleni, emva kokungena egazini, iziyobisi ezininzi zingena kwi-metabolism esibindini, apho ziguqulwa zibe zizinto ezingasebenziyo ngaphambi kokuba zikhutshwe zizintso. Amanye amachiza anokukhutshwa ngokuthe ngqo kwizintso ngaphandle kwemetabolism yangaphambili. Le nkqubo iqinisekisa ukuhanjiswa okusebenzayo kunye nokususwa kwechiza emzimbeni.
Isishwankathelo, ukuxutywa kwe-capsule yinkqubo eyinkimbinkimbi kunye nechanekileyo ebandakanya ukuchithwa kwegobolondo, ukukhululwa kunye nokufunxa iyeza, kunye nefuthe leenguqu zomntu ngamnye. Ukuqondwa ngokufanelekileyo kwale nkqubo kubalulekile kusetyenziso olunengqiqo lwamayeza, ukuqinisekisa ukhuseleko lwawo kunye nokusebenza kwawo. Ukuba kukho naziphi na iimfunoii-capsules ezingenanto, wamkelekile ukuba uqhagamshelane KornnacCaps.
