Njengenye yezinto ezixhaphakileyo ezisetyenziswa ngokuqhelekileyo ekuqulunqweni kwamachiza, iimpawu zokubuyisela amanzi kwi-gelatin ii-capsules ezingenanto zingundoqo ekunqumeni umgangatho kunye nokuzinza kwamalungiselelo eziyobisi. Ukubuyiselwa kwamanzi emzimbeni kubhekiselele kwinkqubo apho i-gelatin capsules iguquka ukusuka kwimeko eyomileyo okanye yeglasi ibuyele kwiimpawu zabo zokuqala zokudumba kunye namandla omatshini phantsi kweemeko ezithile zokusingqongileyo. Olu phawu lunika ngempumelelo ii-capsules nge-Intelligent Activation isakhono, ebenza ukuba badlale indima ebalulekileyo ekuhanjisweni kweziyobisi.
Ubume bePhysicochemical of Rehydration
Ukubuyiselwa kwamanzi kwegelatin iicapsules ezingenanto lutshintsho lwe-gelatin yemolekyuli yamatsheyina ukusuka kwimeko esongiweyo ukuya kwimeko yokudumba ephazamisekileyo. Kwimeko eyomileyo, iimolekyuli ze-gelatin zenza inethiwekhi eqinile ngokusebenzisa iibhondi ze-hydrogen, ezibangelwa ukuthungwa okunzima kunye nokuqina. Ekudibaneni namanzi okanye ulwelo lomzimba, iimolekyuli zamanzi ziyagqobhoza kwaye ziphazamise ezi bhondi zehydrogen, nto leyo ebangela ukuba amatsheyina emolekyuli avuleke kwaye{2}}enze i-elastic three{3}}dimensional hydrogel network. Le nkqubo ichaphazeleka kakhulu ngubushushu, i-pH, kunye namandla e-ionic: phantsi kweemeko ze-37℃(kufuphi nobushushu bomzimba) kunye nokusingqongileyo okungathathi hlangothi, zombini umlinganiselo kunye nobungakanani bokubuyisela amanzi emanzini buphuculwe, kuqinisekiswe ukuchithwa ngokukhawuleza kwe-capsule kwi-vivo ngelixa kuthintela ukuthambisa kwangaphambi kwexesha ngexesha lokugcina ngenxa yokufunxa ukufuma.
IiMpaniso ezingundoqo zeeMpawu zokuBuyiselwa ngamanzi
Iimpawu zokubuyisela amanzi emanzini zibonakaliswa ngokuyintloko kwiinkalo ezintathu: okokuqala, i-kinetics yokuvuvukala{0}}ephezulu{1}}ii-capsules ezisemgangathweni zinokugqiba ukudumba ngaphakathi kwemizuzu eyi-10-15 kulwelo olulinganisiweyo lwamathumbu, kunye nomlinganiselo wokudumba ofikelela kumaxesha angama-5-8 kumthamo wokuqala, ukuqinisekisa ukukhutshwa kweziyobisi ngexesha elifanelekileyo; okwesibini, ukubuyiswa kwamandla omatshini -emva kokubuyiselwa emanzini, amandla okuqhekeka kwe-capsule kufuneka agcinwe phakathi kwe-1.5-2.5N·mm⁻², ngokwaneleyo ukufaka imixholo kwaye ahlale eqinile ngexesha lokuthutha; okwesithathu, ukuchithwa okuhambelanayo, udonga lwe-capsule oluhlaziyiweyo lunyibilika ngokufanayo kwiindawo ezithile ze-pH, ukuthintela ukukhutshwa kwendawo yokukhutshwa kweyeza kunye nokuphucula i-bioavailability.
Ixabiso eliPhambili kwizicelo zoShishino
Kwimiqulu yeziyobisi, iimpawu zokubuyisela amanzi emanzini zichaphazela ngokuthe ngqo ukusebenza konyango. Kwii-capsules ze-enteric, kubalulekile ukulawula i-rehydration threshold ngokusebenzisa iteknoloji yokugqoka, ukuqinisekisa ukuzinza kwindawo ye-acidic gastric ngelixa uvumela ukubuyisela ngokukhawuleza kunye nokuchithwa ekungeneni emathunjini. Ukulungiselela- kunye nokukhutshwa kwemixube elawulwayo{3}}elawulwayo, izinga lokubuyisela amanzi emzimbeni kunye nesantya sokwakheka komaleko odumbileyo ngokudityaniswayo kumisela iprofayile yokukhutshwa kwechiza. Ngaphaya koko, ukuzinza kokubuyisela amanzi emanzini luphawu olungundoqo lobomi beshelufu ye-capsule{5}}phantsi kweemeko ze-25℃kunye ne-60% yokufuma okuhambelanayo,{8}}i-capsules ezisemgangathweni zinokugcina ukusebenza kwazo kokubuyisela amanzi emzimbeni ngaphezu kweminyaka emibini, ziqinisekisa umgangatho kuwo wonke umjikelo wobomi belichiza.
Iimpawu zokubuyisela amanzi emanzinigelatin capsules engenantoimele ukuhlangana kwesayensi yezinto, ikhemistri yomzimba, kunye namayeza. Ngenkqubela phambili kwi-smart excipients, ngokuchanekileyo ukulungelelanisa ukuziphatha kwe-rehydration ngokulungelelanisa imithombo ye-gelatin (umzekelo, umlinganiselo we-Type A ukuya ku-Type B gelatin), idigri ye-crosslinking, kunye nokuguqulwa kwe-composite kunokubonelela abathwali abaphezulu bokuhanjiswa kwechiza ekujoliswe kulo, ukukhutshwa kwe-pulsatile, kunye nolunye uqulunqo lwenoveli{3}}ngokuqhubekayo ukuqhuba ukutsha kwiinkqubo zokuhanjiswa kweziyobisi. Ukuba kukho naziphi na iimfuno kwii-capsules ezingenanto, wamkelekile ukuba uqhagamshelane ne-KornnacCaps.
