Njengomthwali obalulekileyo kumalungiselelo amayeza, ukuzinza kwe-gelatin capsules kuchaphazela ngokuthe ngqo umgangatho kunye nokhuseleko lwamachiza. Phakathi kwezinto ezahlukahlukeneyo ezichaphazela ukuzinza, ukuchithwa kwe-thermal yimpawu ebalulekileyo efuna ingqalelo esondeleyo ngexesha lokugcinwa, ukuthutha, kunye nokusetyenziswa kwezi capsules, njengoko kuchaphazela ngokuthe ngqo ukunyaniseka kwesakhiwo kunye nokusebenza kokukhululwa kweziyobisi.
IGelatin yindalo ephezulu{0}}yemolekyuli{1}}yeprotheyini enobunzima bemolekyuli enamatyathanga emolekyuli agcina i-triple{2}}isakhiwo se-helix ngonxibelelwano olufana ne-hydrogen bond. Xa iqondo lobushushu ambient lidlula ixabiso layo elibalulekileyo, ezi gelatin imixokelelwane molekyuli inguqu ukusuka wayalela isakhiwo helical ukuba disordered isakhiwo ikhoyili random. Le nkqubo yaziwa ngokuba yi-thermal denaturation. Iqondo lobushushu le-thermal denaturation ye-gelatin capsules ngokuqhelekileyo iba phakathi kwe-35℃kunye ne-40 degree, ngexabiso elithile eliphenjelelwa zizinto ezifana nomthombo wegelatin (umzekelo, isikhumba se-porcine, isikhumba senkomo, okanye ithambo lentlanzi), amandla e-bloom, umxholo wokufuma, kunye neentlobo zezongezo ezisetyenzisiweyo. Umzekelo,-ibloom yegelatin ephezulu, kunye neqondo eliphezulu lemolekyuli yomnqamlezo wetsheyina{12}}ukudibanisa, ikholisa ukuba nobushushu obuphezulu be-denaturation, ngelixa ukonyuka kwesiqulatho sokufuma kungenza buthathaka iibhondi ze-hydrogen, okukhokelela kubushushu obusezantsi be-denaturation.
Impembelelo ye-thermal denaturation ekusebenzeni kwe-capsule ibonakala ngokuyinhloko kwiinkalo ezintathu. Okokuqala, kukhokelela ekwehleni kweempawu zoomatshini; amaqokobhe e-capsule enziwe nge-denatured ayathamba, aphulukane ne-elasticity, kwaye athambekele ekuncamatheleni, ekujikeni, okanye nasekugqabhukeni. Okwesibini, iguqula ukungeneka, njengoko ukuhlengahlengiswa kwamatyathanga eemolekyuli kunokunyusa ubungakanani bepore yodonga lwecapsule, okuchaphazela ukuxhathisa kokufuma kwechiza kunye nokukhanya{2}}iipropati zokuthintela. Okwesithathu, kunokubangela ukuchithwa okungaqhelekanga kokusebenza, njengoko i-denaturation inokuphazamisa iipropati zokuvuvukala kwe-gelatin, okubangelwa ukulibaziseka okanye ukukhutshwa kweziyobisi. Umzekelo, kwindawo -zobushushu obuphezulu kunye{6}}nobushushu obuphezulu, iicapsules zinokubonisa isenzeko sokuThamba nokuncamathela, okuchaphazela kakhulu ukupakishwa nokusetyenziswa kwazo.
Ukunciphisa imingcipheko ehambelana ne-thermal denaturation, ukuveliswa kwee-capsules ze-gelatin kufuna ukulungiswa okulungiselelwe. Oku kunokubandakanya ukongeza iiplasticizers ezifana ne-glycerin okanye i-sorbitol ukuphucula ukuguquguquka kwamatyathanga emolekyuli okanye ukusebenzisa i-cross{1}}i-agent zokudibanisa ukuphucula ukuzinza kwe-thermal. Ngexesha logcino, ulawulo olungqongqo kwiqondo lobushushu kunye nokufuma lubalulekile (olufuna iqondo lobushushu elingaphantsi kwe-25℃kunye nokufuma okuhambelanayo ngaphantsi kwe-60%), ukuphepha ukukhanya kwelanga kunye neendawo zokushisa eziphezulu. Ngaphaya koko, imathiriyeli ye-capsule entsha, efana ne-(hydroxypropyl methylcellulose) ii-capsules ze-HPMC, ezinobushushu obuphezulu be-thermal denaturation (inokufikelela ngaphezu kwe-70 degree), ngokuthe ngcembe zibe zezona ndlela zifanelekileyo zokwenziwa kwamachiza ezilungiselelwe iindawo zobushushu obuphezulu{8}.
Ukuqukumbela, i-thermal denaturation luphawu lwendaloiipilisi zegelatinekufuneka ilawulwe ngokulungiswa kwezinto, ulawulo lwenkqubo, kunye nokugcinwa okusemgangathweni. Ukuqondwa ngokucokisekileyo kwesi sakhiwo kubalulekile ekuqinisekiseni umgangatho wamachiza, ukwandisa ubomi beshelufu, kwaye ibonelela ngesiseko sethiyori kuphando kunye nophuhliso lwemathiriyeli ye-capsule entsha. Ukuba kukho naziphi na iimfuno kwii-capsules ezingenanto, wamkelekile ukuba uqhagamshelane ne-KornnacCaps.
