Njengomthwali obalulekileyo kuqulunqo lwangoku lwamayeza,enteric-iqatyweiipilisizisetyenziswa kakhulu kushishino loxubo mayeza ngenxa yoncedo lwazo, njengendawo echanekileyo-ukukhutshwa okuthe ngqo, ukukhusela amachiza ekutshatyalalisweni yi-asidi yesisu, kunye nokuthintela amachiza ukuba angathukutheli ulwelo lwesisu. Nangona kunjalo, ngexesha lokuvelisa kunye nokugcinwa kwangempela, ixesha lokuchithwa kwee-capsules ze-enteric lihlala liyisalathisi esibalulekileyo esinzima ukulawula. Ukulibaziseka ukwahlukana okanye ukukhululwa kwangaphambi kwexesha kuchaphazela ngokuthe ngqo i-bioavailability kunye nempumelelo yonyango yechiza. Ke, zeziphi kanye kanye izinto ezichaphazela ukonakaliswa kwee-enteric{4}}zeipilisi ezigqunyiweyo?
Okokuqala kunye nokuphambili, ukubunjwa kunye neepropati zezinto zeqokobhe zizinto eziphambili ezimisela ukusebenza kokuhlukana.Iipilisi ze-Entericsebenzisa ngokwesiqhelogelatinnjengento esisiseko, eyongezwa ngeepolymers ze-enteric ezifana ne-acrylic resins, i-cellulose acetate phthalate (CAP), okanye i-shellac. Ukuchithwa kwezi zinto ze-enteric kuxhomekeke kwixabiso le-pH yendawo yamathumbu. Ukuba umlinganiselo wokwenziwa kwezinto zokugquma kwe-enteric awufanelekanga{2}}umzekelo, ukuba umlinganiselo wefilimu{3}}uphezulu kakhulu{4}}unokubangela ukuba iqokobhe lingakwazi ukunyibilika okanye ukukhukuliseka ngokukhawuleza kulwelo lwamathumbu, ngaloo ndlela kubangele ukuqhekeka kudlule ixesha elimiselweyo. Ukongeza, amandla eentyantyambo zegelatin, i-viscosity, kunye neqondo lokuwela{6}}ukudityaniswa kokuhlangana kukwachaphazela ngokuthe ngqo ukufunxwa kwamanzi kunye nokusasazeka kweqokobhe lekhepsuli.
Okwesibini,iinkqubo zemvelisokunye neemeko zokugcina zidlala indima ebalulekileyo. Kwinkqubo yokubumba i-capsule, ukulawula ukushisa kokumisa kunye nexesha kubaluleke kakhulu. Ukomisa ngokugqithisileyo kunokukhokelela kumxholo wokufuma ophantsi kakhulu kwiqokobhe, okwenza ukuba ibe brittle kwaye iqine, echaphazela ukumanzisa kwayo kunye nokungena kwamanzi omzimba; ngokuchaseneyo, isiqulatho sokufuma esiphezulu ngokugqithisileyo sinokubangela ukuba iqokobhe lithambe okanye likhubazeke. Okuphawuleka ngakumbi kukuba ukufuma, ubushushu, kunye nokukhanya kwiindawo yokugcinaingaqalisa "umnqamlezo{0}}ukudibanisa" ukusabela kwigelatin. Lo mnqamlezo -ukudibanisa isiphumo senza amanzi{3}}isakhiwo sothungelwano esinganyibilikiyo kumphezulu weqokobhe, okubangela ukuba i-capsule ingaphumeleli ukufunxa amanzi kunye nokuqhekeka ngokwesiqhelo emva kokungena emzimbeni womntu, into eyaziwa njenge "insolubility".
Ekugqibeleni, iipropati zezinto zokuzalisa azikwazi ukuhoywa. Nangona ukwahlukana kujolise ikakhulu kwiqokobhe, impembelelo yesiqulatho yinyani eyinjongo. Ukuba iyeza elizalisiweyo line-asidi eqinile okanye i-alkalinity, okanye iqulethe i-aldehydes ephezulu, inokukhawulezisa ukusabela kweekhemikhali kunye ne-shell material, ibeka engozini ukuzinza kwe-enteric layer. Oku kunokukhokelela ekuqhekekeni kwangaphambi kwexesha esiswini okanye kuthintele ukukhululwa okuqhelekileyo kwi-intestinal fluid.
Isishwankathelo, izinto ezichaphazela ukuchithwa kwee-enteric capsules ezingenanto zininzi, kubandakanywa iimpawu zeekhemikhali zezinto ezibonakalayo, ukulawulwa kweeparitha zokuvelisa, kunye nokuzinza kwendawo yokugcina. Iinkampani zamachiza kufuneka zilawule ngokungqongqo umgangatho wezinto ezikrwada, zongeze iinkqubo zokomisa, kwaye ziqinisekise indawo yokugcina epholileyo neyomileyo. Kuphela ngolawulo olubanzi lwezi zinto apho sinokuthi siqinisekise ukuba i-enteric{2}}i-capsules ezigqunyiweyo ziyaqhekeka kwaye zikhulule ngokuchanekileyo nangempumelelo ngaphakathi emzimbeni, ngaloo ndlela siqinisekisa ukusebenza kwezonyango kwechiza.
