I-Pullulan Capsules, njengohlobo olutsha lwe-capsule yemifuno, ifumene ingqwalasela enkulu ngenxa yeempawu zabo eziluhlaza kunye nezendalo. Eli nqaku liza kunika uhlalutyo olucacileyo lokubunjwa kwee-capsules ze-pululan, kwaye lihlolisise iimpawu zabo ezikhethekileyo zomzimba kunye neekhemikhali, kunye neenzuzo zabo kwizicelo eziphathekayo.
1. Icandelo eliphambili: I-Pullulan
Isithako esisisiseko se-pululan capsules yi-pululan. La manzi endalo -ipolysaccharide enyibilikayo, eguqulwayo ukusuka kwi-sucrose okanye iswekile ukuya phezulu{2}}kwimolekyuli{3}}iipholima ezinobunzima ngokuvundiswa kwemicrobial yi-budding short{4}} yokungunda. Isakhiwo se-molecular of pullulan siyingqayizivele, ngokukodwa siqulunqwe ngamacandelo e-maltotriose adibaniswe yi--1,4 kunye ne-1,6 ye-glycosidic bonds, kunye ne-molecular weight of about 210 Da.
Umthombo wendalo kunye nendlela yokuvelisa indalo ye-pululan yenza kube yinto efanelekileyo ye-capsule yemifuno. Ayinatyhefu kuphela- kwaye ayinavumba, kodwa ikwane-biocompatibility elungileyo kunye ne-biodegradability, enokuthi ihlangabezane neemfuno zamaqela akhethekileyo afana nabatya imifuno kunye namakholwa enkolo.
2. Ukuqulunqwa kwe-Excipient
Ukuqinisekisa iipropati ezibonakalayo kunye nokuzinza kwee-capsules ze-pululan, inani elifanelekileyo labancedisi liya kongezwa ngexesha lenkqubo yokuvelisa. Ezi zincedisi ngokuqhelekileyo ziquka iiplastiki (ezifana ne-glycerin) kunye nezinye izithako zendalo, ezisetyenziselwa ukuphucula ukuguquguquka kunye nokunyibilika kwee-capsules. Izixa ezongezelelweyo zaba bancedisi zincinci kakhulu kwaye aziyi kuba nefuthe elibalulekileyo kwimisebenzi ephambili yee-capsules.
3. Inkqubo yeMveliso
Inkqubo yokuvelisa i-pupulan capsules ithatha i-microbial fermentation njengento engundoqo kwaye idibanisa iteknoloji yokuvelisa i-capsule engenamthungo. Le nkqubo ayigcini nje ngokusingqongileyo kodwa iyasebenza kakhulu, iqinisekisa ukufana kunye nokuzinza komgangatho wee-capsules. Yonke inkqubo yokuvelisa ayibandakanyi iikhemikhali ezinobuthi kwaye ihlangabezana neemfuno zokukhuselwa kokusingqongileyo okuluhlaza.
4. IiPropati zePhysical and Chemical
Iicapsules zePullulan zinothotho lweempawu ezibalaseleyo zomzimba kunye neekhemikhali, zibenza basebenze kakuhle kakhulu kwicandelo lokupakishwa kweziyobisi kunye nezempilo:
Ipropathi egqwesileyo yesithintelo se-Oxygen: I-oxygen permeability ye-pupulan capsules iphantsi kakhulu, malunga ne-1 / 300 ye-hydroxypropyl methylcellulose capsules engenanto, ikhusela ngokufanelekileyo iziqulatho kwi-oxidation.
Ukungangeni kweMichiza: I-Pullulan ayisebenzi ngokwekhemikhali kwaye ayiyi kuphinda isebenze okanye idityaniswe-nemixholo yayo, iqinisekisa uzinzo kunye nokusebenza kakuhle kwechiza.
Ukukhuselwa kokusiNgqongileyo kunye nokuthotywa: I-Pullulan ithathwe kwimithombo evuselelekayo. Iicapsules zinokuguqulwa ngokupheleleyo kwaye zihambelana nokusingqongileyo.
Ukusetyenziswa ngokubanzi: Iipilisi ze-Pullulan aziqulathanga izithako zezilwanyana- kwaye zifanelekile kubantu abaneenkcubeko ezikhethekileyo zokutya ezifana nemifuno, amaMuslim, kunye namaJuda.
I-capsule ye-pullulan, kunye ne-pululan njengesona sithako esiphambili, esidibaniswe nabancedisi bendalo kunye nobuchule obuphambili bokuvelisa, kubonisa iimpawu ezibalaseleyo zomzimba kunye neekhemikhali. Iimpawu zayo zokuba luhlaza, zihambelana nokusingqongileyo, zikhuselekile kwaye zisebenza ngokufanelekileyo zenza ukuba zibe nethemba elibanzi lesicelo kwintsimi yokupakisha imveliso yeziyobisi kunye nempilo. Ngophando olunzulu - lwe-pululan, i-capsules capsules kulindeleke ukuba idlale indima enkulu kwixesha elizayo kwaye yenze igalelo elingakumbi kwimpilo kunye nokukhuselwa kwendalo. Ukuba kukho naziphi na iimfuno kwii-capsules ezingenanto, wamkelekile ukuba uqhagamshelane ne-KornnacCaps.
