Kumashishini amayeza kunye nesondlo, ii-capsules ezingenanto zisebenza njengabathwali beziyobisi. Umsebenzi wabo ophambili ayikokugquma imixholo kuphela kodwa, okona kubaluleke kakhulu, kukugqabhuka ngokukhawuleza kwiindawo ezithile ngaphakathi emzimbeni ukukhulula ichiza. Umda wexesha lokuqhawula ubhekisela kwixesha elifunekayo ukuze i-capsule itshintshe ukusuka kwisimo esiqinileyo ukuya kwisimo esingenasiphelo kwisimo esicacisiweyo; esi sisalathisi esibalulekileyo sokulinganisa umgangatho we-capsule. Ngenxa yokungafani kwesakhiwo samakhemikhali kunye neempawu ezibonakalayo, iintlobo ezahlukeneyo zee-capsules ezingenanto zibonisa ukuhlukana okuphawulekayo kwimida yazo yexesha lokuchithwa.
Okwangoku, ii-capsules ezingenanto eziqhelekileyo kwimarike zohlulwe ngokukodwa kwii-capsules ze-gelatin (izilwanyana-ezifunyenwe) kunye nemifuno yemifuno (ingakumbi i-HPMC capsules kunye ne-Pullulan capsules).
Okokuqala,iipilisi zegelatinYeyona fom yedosi eneyona mbali inde. Icandelo labo eliphambili lithatyathwe kulusu lwesilwanyana kunye ne-collagen yamathambo, ene-hydrophilicity egqwesileyo. Kwimeko eqhelekileyo ye-gastric fluid (i-37 degree, i-aqueous medium), i-gelatin capsules ithatha amanzi kwaye yanda ngokukhawuleza, kunye negobolondo ngokukhawuleza ukuthambisa kunye nokuchithwa. Ngokwe-Pharmacopoeia yaseTshayina kunye nemigangatho efanelekileyo, umda wexesha lokuchithwa kwee-gelatin capsules ngokuqhelekileyo kufuneka ube phakathi kwemizuzu engama-30. Ngenxa yokunyibilika kwazo -zamanzi, iipilisi zegelatin zibonelela ngokuqala ngokukhawuleza kwaye lolona khetho lukhethwayo kumachiza aqhelekileyo.
Okwesibini,Iipilisi zeHPMCzezona capsules zemifuno zisetyenziswa kakhulu. Ngokungafaniyo ne-gelatin, i-HPMC yi-derivative cellulose kunye nesakhiwo sekhemikhali esizinzileyo. Indlela yokuchithwa kwe-capsule ye-HPMC emanzini inobudlelwane obuphantsi kunye nobushushu kwaye ayichatshazelwa kakhulu ngexabiso le-pH. Nangona ixesha labo lokuqhekeka likwahambelana nemfuno ye-pharmacopoeia phakathi kwemizuzu engama-30, ii-capsules ze-HPMC zihlala zibonisa ukuziphatha okuzinzile ngakumbi kokuqhekeka ngexesha lenkqubo yokutshatyalaliswa. Ingakumbi kwindawo ephantsi-yobushushu okanye{6}}phezulu{6}}kwiimekobume zokufuma, ii-capsules ze-HPMC zigcina ubuqhophololo kunye nokunyibilika kakuhle; abakhathazwa kukwandiswa kwexesha lokuqhekeka ngenxa yokuwela{7}}kunxulumanisa ukusabela (ukwaluphala) njengoko iipilisi zegelatin ngamanye amaxesha zisenza.
Ukongeza, kwiimfuno ezizodwa, kukho i-enteric{0}}ikhepsuli ezigqunyiweyo kunye{1}}nokukhutshwa okuzinzileyo. Nokuba i-matrix yigelatin okanye ifayibha yesityalo, i-enteric{3}}iikhepsuli ezigqunyiweyo zifumana unyango olukhethekileyo lokugquma okanye ukuguqulwa kweekhemikhali. Abayi kuchithwa kwindawo ye-asidi yesisu kwaye bachithe kuphela emva kokungena kwindawo ethile ye-pH yamathumbu. Umda wabo wexesha lokuqhekeka ufuneka ngokuqhelekileyo ukuba ube ngaphakathi kweyure ye-1 kwi-intestinal intestinal fluid, ewela phantsi kwecandelo lokukhululwa okulawulwayo.
Isishwankathelo, iipilisi eziqhelekileyo ze-gelatin kunye neepilisi zemifuno zinemilinganiselo yexesha elifanayo lokuchithwa kwemilinganiselo (zombini ngaphakathi kwemizuzu ye-30), kodwa i-capsules yemifuno yenza ngcono ngokuzinza phantsi kweemeko ezigqithisileyo kunye nokuchasana nokuguga. Xa ukhetha iintlobo ze-capsule, iinkampani zoxubo-mayeza kufuneka ziqwalasele ngokubanzi iipropati zamachiza, iimeko zokugcina, kunye neemfuno ezichanekileyo zesantya sokuqhekeka ukuqinisekisa ukufumaneka kwe-bioavailability yechiza.
