Ngaba wakha wazibuza ukuba kutheni bekrelekrele xa ufumana iipilisi kwibhokisi yakho yamayeza ekufuneka ithathwe kwisisu esingenalutho ayibangeli isisu esibuhlungu? Impendulo ikwiqokobhe lazo elingaphandle, i-enteric{0}}capesule eqatywe. Ngoko, yintoni kanye kanyeenteric-iqatyweiipilisiyenziwe nge? Namhlanje, masiphakamise isigqubuthelo kwimfihlakalo yayo.
Amacandelo angundoqo: Ukuguqulwa kweGelatin okanye iGel yeSityalo
Eyona mathiriyeli ye-enteric{0}}egqunywe iicapsules iqhelekile igelatin. IGelatin yiprotheyini ekhutshwa emathanjeni esilwanyana okanye eluswini, eyaziwa ngokuba yifilim entle{2}}yokwenza iipropathi kunye nokuhambelana nebhayoloji, iyenza ibe lukhetho lwemveli lokwenza amaqokobhe eecapsule eziqhelekileyo. Ukuhlangabezana neemfuno ezikhethekileyo zamachiza athile kwi-gastrointestinal tract, ezi zixhobo ezisisiseko zifuna ukulungiswa kwesibini.
Into engundoqo: I-Enteric Coated Layer
Isizathu sokuba i-enteric{0}}i-capsules ezigqunywe zihlale ililitye{1}}eqinile esiswini kwaye zophuka ngoko nangoko emathunjini ilele kumaleko okhethekileyo agqunywe kwi-enteric kumphezulu weqokobhe le-capsule. Le nto yokwambathisa isitshixo sokumisela ukusebenza kwayo. Iimathiriyeli eziqhelekileyo{4}ezigqunyiweyo ziwela ikakhulu kumacandelo amabini:
I-Cellulose Derivatives: Njenge-cellulose acetate phthalate (CAP), i-hydroxypropyl methylcellulose phthalate (HPMCP), njl. Ezi zinto zizinzile kwaye ziphantse zinganyibiliki kwindawo ene-acidic yejusi yesisu, ngaloo ndlela ikhusela iyeza langaphakathi. Xa i-capsule ifikelela kwindawo yamathumbu enexabiso eliphezulu le-pH, ezi zixhobo zinyibilika, zibangela ukuba igobolondo le-capsule livuleke kwaye likhulule iyeza.
I-Acrylic Resins: Ezi resins zikwanophawu lokuzinza kwindawo ene-acidic kunye nokunyibilika kwindawo yealkaline, izenza enye into esetyenziswa ngokuqhelekileyo.
IiMfuneko eziKhethekileyo:-Ezizezinye eziSekwe kwiZityalo
Ukuthathela ingqalelo iimfuno zamaqela athile abantu (abanje ngabatya imifuno okanye abo badibaniyo neemveliso zezilwanyana), kukwakho nee-enteric{0}}iikhepsuli ezigqunyiweyo kwimarike ezenziwe ngejeli yezityalo (ezifana ne-HPMC) njengesiseko emva koko zinyangwe nge-enteric coating. Oku kunika iinketho ezininzi kwizigulane.
Isithuba sangaphakathi: Indawo ekhuselekileyo yeziyobisi
Indawo engenanto ye-enteric -ecatyiswe capsule iyilelwe ukumela ichiza. Inokuzaliswa ngeendlela ezahlukeneyo zedosi yamachiza, nokuba zingumgubo, iigranules, okanye iipellets. Le asidi -iqokobhe le-capsule elixhathisayo lisebenza njengendawo ekhuselekileyo yethutyana, liqinisekisa ukuba ichiza lihlala lizinzile phambi kokuba lifike kwindawo ekujoliswe kuyo (amathumbu), alitshatyalaliswa sisisu se-asidi, kwaye linqanda ukucaphuka kwi-gastric mucosa.
Isishwankathelo: UMlondolozi wezeMpilo oyilwe ngokuchanekileyo
Ukuququmbela,i-enteric-capesule eqatyweyenziwe ngezinto ezisisiseko (igelatin okanye ijeli yesityalo) kunye ne-enteric layer coating (efana neCAP, HPMCP, njl.). Olu luyilo luchanekileyo luyivumela ukuba ihambise amayeza emathunjini ngokuchanekileyo, idlala indima engenakuphinda ithathelwe indawo ekukhuseleni ukusebenza kweziyobisi, ukunciphisa iziphumo ebezingalindelekanga zesisu, kunye nokuphucula ukusebenza kweziyobisi. Kwixesha elizayo xa uthatha i-enteric-capsule eqatywe, mhlawumbi unokuba nokuqonda ngakumbi kunye nentlonipho yale ngubo incinci ingabonakaliyo. Ukuba ufuna ukufunda banzi malunga ne-enteric{5}}ikhepsuli ezigqunyiweyo okanye izinto eziyeleleneyo zamayeza, nceda uzive ukhululekile ukuqhubeka usilandele.
