Njengomthwali obalulekileyo kuqulunqo lwale mihla lwamayeza, ukuvela kwee-capsules ezinzima ezingenanto kubonisa ukuqhubela phambili kwamayeza ukusuka kwisithethe ukuya kwizenzo zangoku. Lo mxhasi weyeza obonakala ulula akajongi nje imiba enjengobukrakra kunye nokucaphuka kwamachiza ngexesha lolawulo kodwa ukwaqhubele phambili ukubekwa emgangathweni kunye nesikali soshishino loxubo mayeza, ibe licandelo eliyimfuneko kwiifom zedosi yechiza.
Iprototype yee-capsules inokulandelwa kwi-Egypt kunye neGrisi yakudala, apho abantu babesebenzisa amathumbu ezilwanyana okanye i-bewax ukusonga amayeza ukufihla ivumba elibi okanye ukwenza lula ukuginya. Nangona kunjalo, i-capsule yokwenyani engenanto yazalwa phakathi kwenkulungwane ye-19 eFransi. Ngo-1834, usokhemesti waseParis u-Achille Colas wenza indlela yokuvelisa i-gelatin capsules ngokudipha ukubumba ukwenza amaqokobhe e-capsule, ukufikelela kwi-encapsulation yeyeza elisemgangathweni okokuqala. Olu qulunqo lwakhawuleza lwasasazeka kulo lonke elaseYurophu lwaza lwafikelela eUnited States ngasekupheleni kwenkulungwane ye-19, nto leyo eyabangela ukuveliswa kwemveliso yeecapsules.
Ekuqaleni kwenkulungwane yama-20, ngokunyuka kweshishini lamayeza, itekhnoloji yokuvelisa ii-capsules ezinzima ezingenanto ziye zaphumelela kakhulu. Kwi-1912, usokhemesti waseMelika uRobert Paul Scherer waqulunqa umatshini wokwenza i-capsule ozenzekelayo, ovumela ukuveliswa okuqhubekayo kunye nokuphucula kakhulu ukusebenza kakuhle kunye nokuhambelana kwemveliso. Ngeli xesha, igelatin yaye yasetyenziswa kakhulu njengeyona nto iphambili kwi-capsule, kwaye ubukhulu be-capsule babulungelelaniswa ngokuthe ngcembe, benza inkqubo yesayizi eqhelekileyo ngoku ukusuka ku-00 ukuya ku-5.
Emva kweMfazwe Yehlabathi II, kunye nokwanda kwemarike yamayeza yehlabathi, ishishini le-capsule elingenanto langena kwixesha lokukhula ngokukhawuleza. Ngeminyaka yoo-1960, ukuvela kwe-enteric{2}}ikhepsuli ezigqunyiweyo kwayisombulula ingxaki yamachiza atshatyalaliswa lula esiswini. Ngeminyaka yee-1970, iipilisi zemifuno zavela ukuze zihlangabezane neemfuno zabantu abatya imifuno kunye nabantu abaneenkolelo ezithile zonqulo. Ukungena kwinkulungwane yama-21, ukusetyenziswa kwezinto ezintsha zepolymer kuye kwaqhuba uphuhliso lwee-capsules ezisebenzayo, ezifana ne-capsules eqhubekayo{7}}ekhutshiweyo kunye ne-capsules ejoliswe kuyo{8}}ekukhululwe kuyo, ukuphucula kakhulu iziphumo zonyango.
Kwangaxeshanye, iinkqubo zemveliso zavela kwindlela yemveli yokudipha ukuya kwindlela esebenzayo yokulahla, yonyusa impumelelo yemveliso kaninzi. Imigca yemveliso yee-capsule zangoku inolawulo oluzenzekelayo olupheleleyo, nomgangatho wemveliso udibana nemigangatho yemigangatho yonyango{1}}. Imveliso ye-capsule yonyaka kwihlabathi jikelele igqithise i-trillion ye-trillion, kunye ne-China, i-United States, kunye ne-Japan abavelisi abahamba phambili.
Namhlanje,ii-capsules ezinzima ezingenantozivele kwisixhobo esilula sokuhanjiswa kwechiza ukuya kwindlela -yobuchwephesha bokuhanjiswa kweziyobisi. Azithwali kuphela izithako ezisebenzayo zoxubo mayeza kodwa zikwaquka ukufuna okungayekiyo koluntu kokuchaneka kulawulo lwamachiza. Ngokuphumelela kwitekhnoloji yoshicilelo lwe-3D, i-nanomaterials, kunye nezixhobo zokuphendula ezihlakaniphileyo, ii-capsules ezingenanto ezilukhuni zisetelwe ukuba zikhanye ngakumbi kwiinkalo zeyeza lomntu, unyango lwemfuza, kunye nokuhanjiswa kweziyobisi ezijoliswe kuyo, ukuqhubeka nokubhala isahluko esiqaqambileyo kwinkqubela phambili yesayensi yonyango kunye nobuchwepheshe. Ukuba kukho naziphi na iimfuno kwii-capsules ezingenanto, wamkelekile ukuba uqhagamshelane ne-KornnacCaps.
