Iicapsules ezingenanto zisebenza njengabathwali ababalulekileyo bamayeza kunye ne-nutraceuticals, kwaye iimpawu zabo zomzimba zinovakalelo olugqithisileyo. Phakathi kwezi, isiqulatho sokufuma sisalathisi somgangatho. Ukufuma okugqithisileyo kunokubangela ukuba ii-capsules zibe thambileyo, zikhubazeke, okanye zinamathele kunye, ngelixa ukufuma okunganeleyo kuzenza zibe brittle kwaye zithande ukuqhekeka ngexesha lokuthutha kunye nokugcinwa. Ke ngoko, ngokwesayensi kunye ngokuchanekileyo ukufumanisa umxholo wokufuma kwiicapsules ezingenanto yinxalenye eyimfuneko yolawulo lomgangatho kwiinkampani zamayeza.
Okwangoku, ukufunyanwa komswakama womswakama kwii-capsules ezingenanto kuxhomekeke ngokuyinhloko kumgaqo wokutshintsha ubunzima bomzimba kunye nohlalutyo lweekhemikhali. Kuvavanyo oluqhelekileyo oluchazwe yi-pharmacopeias, eyona ndlela isetyenziswa ngokuqhelekileyo yindlela yoLahleko loKumisa (LOD). Oku kubandakanya ukufudumeza isampulu ukuze amanzi abe ngumphunga, kwaye emva koko ubale umthamo wokufuma ngokusekelwe kumahluko wobunzima phambi nasemva kokoma. Kwii-capsules ze-gelatin, ulawulo olungqongqo lobushushu ngexesha lovavanyo lubalulekile ngenxa yobuntununtunu be-thermal; I-oveni yobushushu obungaguqukiyo isetyenziswa ngokuqhelekileyo. Ukuthintela i-thermal denaturation ye-gelatin, ukomiswa kwe-vacuum ngamanye amaxesha kusetyenziswa, ukuvumela umswakama ukuba uphuphe kumaqondo okushisa aphantsi phantsi koxinzelelo oluncitshisiweyo. Nangona le ndlela yakudala ivelisa iziphumo ezichanekileyo, ihlala ixesha{5}}idla kwaye liyasokola ukuhlangabezana nemfuno yempendulo ekhawulezayo kwimigca yemveliso yangoku.
Ukuphucula ukusebenza kakuhle kovavanyo, abahlalutyi bokufuma ngokukhawuleza bafumene ukusetyenziswa okuxhaphakileyo kumzi mveliso kwiminyaka yakutshanje. Ezi zixhobo ngokuqhelekileyo zisebenzisa i-halogen yokufudumeza okanye iteknoloji ye-infrared radiation ukutshisa iisampulu ngokuthe ngqo, inciphisa kakhulu ixesha lokumisa. Umgaqo wabo wokusebenza usekwe ekulahlekeni kobunzima, kodwa badibanisa{2}}izinzwa ezichanekileyo eziphezulu kunye neenkqubo ezikrelekrele zokulawula ubushushu ukuze bajonge ngokuzenzekelayo utshintsho kubunzima besampulu kwaye babale umxholo wokufuma ngexesha lokwenyani. Xa kuthelekiswa neendlela ze-oveni zesiNtu, le ndlela iphelisa imfuneko yokuphinda-phindwa komlinganiselo kunye nokupholisa ngesandla, inika iziphumo kwimizuzu, iyenza ilungele{4}}kulawulo lwenkqubo kunye nokuhlolwa ngokukhawuleza ngexesha lemveliso.
Ngaphandle kweendlela ezisekelwe kwimigaqo ye-thermogravimetric, i-Karl Fischer titration yenye indlela ebalulekileyo yokufumanisa. Le ndlela yeekhemikhali imisela isiqulatho sokufuma ngokusekwe kubungakanani bokusabela kweekhemikhali phakathi kwe-iodine namanzi. Kwiicapsules ezingenanto ezinobushushu obugqithisileyo{2}}okanye eziqulathe izinto eziguquguqukayo, iKarl Fischer titration ibonelela ngokuchaneka okuphezulu kakhulu kwaye inokubona umkhondo wokufuma. Nangona kunjalo, ngenxa yeemfuno zayo eziphezulu zee-reagents kunye nokusingqongileyo, kunye nokuntsonkotha kwayo okuhambelanayo, iqhele ukusetyenziselwa uhlalutyo lolamlo okanye imimandla yophando endaweni yokhetho oluphambili lwemveliso yemihla ngemihla.
Ngaphaya koko, ngophuhliso lwemveliso ekrelekrele kumzi-mveliso wamayeza, i-Near{0}}I-Infrared Spectroscopy (NIR) nayo iqalisile ukusetyenziswa ekubhaqweni kwe-intanethi yokufuma kwe-capsule. Le -indlela yokuvavanya engonakalisiyo iqikelela isiqulatho sokufuma ngokuhlalutya uphawu lokufunxa imbonakalo yeesampulu kufutshane-kuluhlu lokukhanya kwe-infrared kudityaniswe nemifuziselo yezibalo. Inzuzo yayo enkulu ibandakanya akukho ntshabalalo yesampulu, akukho zixhobo zokuvuselela, kunye nezantya ezikhawulezayo zokubona, ukwenza ixesha lokwenyani, ukubek'esweni okuqhubekayo kunye nokumela umkhombandlela obalulekileyo wolwakhiwo lwexesha elizayo lweefektri ezikrelekrele.
Ngamafutshane, kukho iindlela ezahlukeneyo zokubona ukufuma kweii-capsules ezingenanto. Kwizicelo ezisebenzayo, amashishini kufuneka akhethe indlela efanelekileyo yokubona ngokusekwe kwiimfuno zenkqubo ethile, ukuchaneka okufunekayo, kunye nesantya semveliso. Ingaba usebenzisa indlela ye-oven yendabuko okanye abahlalutyi banamhlanje abakhawulezayo, ukuqinisekisa ukuchaneka kunye nokuzinza kwedatha yokufumanisa ekugqibeleni kujoliswe ekuqinisekiseni umgangatho wee-capsules ezingenanto, ngaloo ndlela kuqinisekiswe ukhuseleko kunye nokusebenza kakuhle kweemveliso zonyango. Ukuba kukho naziphi na iimfuno kwiicapsules ezingenanto, Wamkelekile ukuba uqhagamshelane ne KornnacCaps.
